Human Biology 2025 May / June
Download free Edexcel IGCSE Human Biology 2025 May / June question papers and mark schemes.
About Edexcel IGCSE Human Biology 2025 May / June Past Papers
This page provides free access to the official Pearson Edexcel IGCSE Human Biology (4HB1) 2025 May / June past papers with mark schemes. These past papers are the most effective revision resource for students preparing for their IGCSE Human Biology examinations.
Master Edexcel IGCSE Human Biology with organised past paper questions and detailed mark schemes. The 2025 May / June papers cover all 12 topic areas of the specification.
Topics in Edexcel IGCSE Human Biology
Cells and tissues
Cell ultrastructure, DNA structure and replication, protein synthesis, mitosis, stem cells, tissue and organ organisation, genetic engineering.
Biological molecules
Structure of carbohydrates, proteins and lipids; food tests (Benedict's, iodine, Biuret); enzyme action and kinetics; immobilised enzymes.
Movement of substances in and out of cells
Diffusion, osmosis and water potential, active transport, surface area to volume ratio.
Bones, muscles and joints
Axial and appendicular skeleton, bone structure, synovial joints, antagonistic muscle action, osteoporosis.
Coordination
Nervous system, nerve impulses and synapses, reflex arc, endocrine system, eye, ear, drugs and their effects, mental illness, neurodegenerative diseases.
Nutrition and energy
Balanced diet, deficiency diseases, digestive system, enzymes in digestion, absorption in small intestine, dental health, obesity.
Respiration
Aerobic and anaerobic respiration, ATP and energy transfer, oxygen debt.
Gas exchange
Ventilation mechanism, gas exchange in alveoli, lung volumes, exercise and cardiovascular response, effects of smoking.
Internal transport
Blood composition, blood vessels, heart structure and function, cardiovascular disease, blood pressure, monoclonal antibodies.
Homeostatic mechanisms
Homeostasis and negative feedback, temperature regulation, kidney structure and function, osmoregulation, blood glucose regulation, liver.
Reproduction and heredity
Meiosis, reproductive systems, menstrual cycle, pregnancy, contraception, IVF, genetics and inheritance, inherited conditions, gene therapy.
Health, disease and immunity
Types of disease, pathogens, disease transmission, immune response, phagocytosis, antibodies, vaccination, antibiotics and resistance, cancer.
How to Revise with Past Papers
- Download the Question Paper and attempt it under timed, exam conditions.
- Mark your answers using the official Mark Scheme — note where marks were lost.
- Identify weak topics and revisit those sections before trying another paper.
- Use GradeMax topic-wise questions to drill specific areas until confident.